Traumatic ulcerative granuloma with stromal eosinophilia mimicking a squamous cell carcinoma.

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare lesion of a traumatic-reactive nature of the oral mucosa that can clinically mimic an oral carcinoma. A 59-year-old male patient presented painful ulceration with indurated margins on the base of the tongue, extending to the floor of the mouth. The use of ill-fitting denture hurting the mucosa of the region was reported by the patient. The evolution time was 45 days. The presumptive diagnoses were oral squamous cell carcinoma and chronic ulcer. An incisional biopsy revealed an ulceration associated with an eosinophil-rich inflammatory infiltrate and a bed of proliferating histiocyte-like cells in either diffuse or fasciculate arrangement. There was diffuse immunopositivity for CD3, but focal for CD68 and α-SMA, and negativity for CD30. The final diagnosis was TUGSE. The use of the ill-fitting dental prosthesis was suspended and the lesion had complete spontaneous remission three weeks later. TUGSE is an uncommon traumatic self-limiting lesion that must be included in the differential diagnosis of ulcerative lesions resembling oral cancer. The correlation of clinical and histopathological findings is pivotal for a proper diagnosis, avoiding unnecessary aggressive surgical approaches. Key words:Oral ulcer, eosinophilia, immunohistochemical, differential diagnosis.

Medication-related osteonecrosis in torus palatinus: Report of a case and literature review.

BACKGROUND: Medication-related osteonecrosis of the jaw bones have been frequently reported. However, its occurrence in torus palatinus is very rare with only 10 cases published in the English-language literature. CASE REPORT: We describe an additional case in a 79-year-old woman, who was referred for evaluation of a painful swelling with areas of suppuration on the hard palate. CONCLUSION: Conservative treatment was performed and after spontaneous sequestrectomy, total healing was achieved.

A primary oral mucosal melanoma of the hard palate with no recurrence: Report of a 10 years follow-up.

BACKGROUND: Primary oral mucosal melanoma (OMM) represents an extremely rare and aggressive tumor that arises from malignant transformation and clonal expansion of melanocytes in the oral cavity. The prognosis of patients affected by OMM is quite unfavorable, with survival rates lower than those described for patients with cutaneous melanoma. CASE REPORT: Here, we report a case of OMM in a 59-year-old Caucasian woman, who was referred for evaluation of a large asymptomatic pigmented lesion on the left side of the hard palate under the removable total denture. Incisional biopsy was performed, and histopathological analysis revealed the proliferation of spindle-shaped and pigmented epithelioid cells, with cellular pleomorphism. These cells were positive for Melan A, S-100, HMB-45, SOX-10, and Ki-67 confirming the diagnosis of OMM. The patient underwent partial maxillectomy and adjuvant radiotherapy. After treatment, she was rehabilitated with a palatal obturator prosthesis and has been in follow-up for 10 years with no evidence of disease. Due to the rarity in the oral cavity and the nonspecific signs and symptoms, the diagnosis of OMM is difficult and often overlooked. CONCLUSION: Therefore, multidisciplinary management from diagnosis, treatment, and rehabilitation is important to increase the expectation of cure.

Lingual metastasis as the first presentation of clear cell renal cell carcinoma: Report of a rare case clinically mimicking a benign lesion.

Metastases in the oral cavity are rare and frequently associated with widespread disease and poor prognosis. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), known for its propensity for metastatic spread. The diagnosis of oral metastases from ccRCC is challenging, especially when the patient has no history of primary neoplasm. Herein, we reported a rare metastatic ccRCC in a 58-year-old female presenting clinically as a painless nodule on the tongue mimicking a benign lesion. Microscopically, the tumor showed a proliferation of clear cells organized in nests with a predominantly lobular arrangement. The dense connective tissue stroma was highly vascularized, exhibiting some areas with a hyalinized aspect. Immunohistochemistry showed focal positivity for pan-cytokeratin AE1/AE3 and strong positivity for CK8, CK18, epithelial membrane antigen (EMA), vimentin, and CD10. S-100 protein, HMB-45, CK7, and CK20 were negative. The definitive diagnosis was metastatic ccRCC. The treatment was initiated with sunitinib. However, the disease progressed, and the patient was submitted to palliative care. Despite the low survival rate of patients with metastases, the clinician's experience in identifying an oral metastatic lesion may reveal undiagnosed primary tumors and provide better prognosis and survival rates.

A recurrent leiomyosarcoma of the buccal mucosa: An immunohistochemistry study and literature review.

Leiomyosarcoma is a rare type of cancer that affects smooth muscle tissue. Leiomyosarcomas are exceedingly rare in the oral cavity, particularly in the buccal mucosa. The diagnosis is challenging due to non-specific clinical features and significant overlap of morphological findings with several spindle cell tumors. We reported the clinicopathological and immunohistochemical features of a rare recurrent case of leiomyosarcoma in a 73-year-old female presenting clinically as a painful nodule on the posterior right buccal mucosa. Microscopically, the lesion showed atypical spindle cells arranged in a fascicular pattern and frequent mitotic figures. Immunohistochemistry showed strong positivity for vimentin, α-SMA, HHF35, h-caldesmon, and focal positivity for desmin. CD34 highlighted numerous blood vessels distributed throughout all tumor stroma. S-100 protein, myogenin, and pan-cytokeratin (AE1/AE3) were negative. Surgical excision followed by chemotherapy was carried out, and no recurrence was observed after 1 year of follow-up. Careful histopathological and immunohistochemistry analysis of these lesions is essential to ensure a correct diagnosis. Early surgical excision with tumor-free margins and prolonged follow-up is strongly recommended.

Fat-free pleomorphic lipoma of the buccal mucosa: An immunohistochemical study and literature review.

Pleomorphic lipomas are extremely rare in the oral cavity. Due to the significant overlap of morphological findings with several benign and malignant soft tissue tumors, especially in the absence of adipocytes, the diagnosis is challenging. We reported the clinicopathological and immunohistochemical features of an uncommon case of a fat-free variant of pleomorphic lipoma in a 48-year-old female presenting clinically as a painless nodule on the buccal mucosa. Microscopically, the lesion showed atypical spindle cells, numerous floret-like giant multinucleated cells, and abundant ropey collagen fibers bundles. Immunohistochemistry showed strong positivity for vimentin and CD34. Mast cell tryptase highlighted numerous mast cells distributed throughout all tumor stroma. S-100 protein, pan-cytokeratin, desmin, α-SMA, EMA, CD68, STAT6, Bcl-2, MDM2, and CDK4 were negative. Conservative surgical excision was carried out, and no recurrence was observed after 13 months of follow-up. Careful histopathological and immunohistochemistry analysis of these lesions is recommended to ensure the correct diagnosis and provide adequate management through a conservative surgical approach. To the best of our knowledge, this is the second case of fat-free pleomorphic lipoma in the oral cavity.

Cisto residual ectópico em associação a corpo estranho: relato de caso / Ectopic residual cyst in association a foreign body: case report

Introdução: O cisto residual é uma lesão de origem inflamatória, associada a uma falta de curetagem adequada do alvéolo de um dente que mostrou lesão inflamatória periapical. Quando não existe fonte de estímulo, tende a regredir, acometendo, frequentemente, o sexo masculino de idade média avançada e com um ou mais dentes extraídos. Relato de caso: Este trabalho tem como intuito apresentar um relato de caso de um paciente do sexo masculino com 69 anos de idade que procurou a Clínica Escola de Odontologia do Centro Universitário CESMAC, com uma fístula de drenos ativos na região anterior de maxila, sem abaulamento ou crescimento dos tecidos circundantes. Ao exame clínico intrabucal, foi observado ausência de todos os dentes superiores, com fístula e drenagem ativa, sem abaulamento das corticais. O exame radiográfico panorâmico mostrou presença de lesão radiolúcida, unilocular, circunscrita por halo radiopaco semelhante a cisto residual. A biópsia excisional foi conduzida com remoção da raiz residual, além de corpos estranhos introduzidos pelo paciente. Considerações Finais: Diante do exposto, deve-se dar importância ao assunto para alertar o cirurgião-dentista quanto ao correto diagnóstico diferencial das lesões ósseas com associação clínica, radiográfica e histopatológica, possibilitando o tratamento adequado e evitando a permanência e crescimento da lesão... (AU)

Introduction: The residual cyst is a lesion of inflammatory origin associated with a lack of adequate curettage of the alveolus of a tooth that showed periapical inflammatory lesion. When there is no source of stimulation, it tends to regress. It frequently affects males from middle to advanced age and with one or more extracted teeth. Case report: This case report a male patient, 69 year old who sought out the Clinical School of Dentistry of the Centro Universitário CESMAC, with a fistula of active drains in the anterior region of the maxilla, without bulging or growth of the surrounding tissues. Intraoral buccal examination showed absence of all upper teeth, with fistula and active drainage without cortical bulging. Panoramic radiographic examination showed the presence of a radiolucent, unilocular lesion, circumscribed by radiopaque halo as a cystic residue. Excisional biopsy was performed with residual root removal in addition to the wooden barb introduced by the patient. Final considerations: In view of the above, it was developed as a reference for the dental surgeon's warning regarding the differential diagnosis of the lesions with the clinical, radiographic and histopathological association, allowing adequate treatment and remaining and lesion growth... (AU)

Mesiodentes na dentição mista: relato de caso / Mesiodens in mixed dentition: case report

Os dentes supranumerários são dentes adicionais à série normal e podem ocorrer em qualquer região da arcada dentária, entretanto, são comumente encontrados em maior número na maxila. O termo mesiodente refere-se ao dente supranumerário localizado na região da pré-maxila, mais precisamente entre os incisivos centrais superiores, e é o tipo mais frequente de supranumerário. Este artigo apresenta o caso clínico de uma criança de 08 anos de idade, gênero masculino, cujos pais procuraram por tratamento com queixa de não esfoliação dos incisivos superiores permanentes. Foram realizados exames clínicos e radiográficos e estes demonstraram a presença de dois dentes mesiodentes impedindo a irrupção dos permanentes. O objetivo do trabalho é enfatizar a importância de um diagnóstico precoce para evitar possíveis complicações e auxiliar no planejamento cirúrgico(AU)

Supernumerary teeth are additional teeth to the normal range and can occur in any region of the teeth, however, they are commonly found in the maxilla. The term mesiodens refers to the supernumerary tooth located in the region pre - jaw, more precisely between the upper central incisors and is the most common type of supernumerary. This article presents a case of a child, 08-years-old, male, whose parents sought treatment for complaining of no exfoliation of the permanent incisors. Clinical and radiographic examinations were performed and these showed the presence of two mesiodens teeth preventing the eruption of the permanent. The aim is to emphasize the importance of an early diagnosis to prevent possible complications and assist in surgical planning(AU)